Regenerative Medicine Studies

Click the links below to expand each section for current regenerative medicine research by topic.

The Role of Platelet Rich Plasma (PRP) and Other Biologics for Rotator Cuff Repair. Greenspoon JA, Moulton SG, Millett PJ, Petri M. Open Orthop J. 2016 Jul 21;10:309-314. eCollection 2016 Jul 21.

Impact of Platelet-Rich Plasma on Arthroscopic Repair of Small- to Medium-Sized Rotator Cuff Tears: A Randomized Controlled Trial. Holtby R, Christakis M, Maman E, MacDermid JC, Dwyer T, Athwal GS, Faber K, Theodoropoulos J, Woodhouse LJ, Razmjou H. Orthop J Sports Med. 2016 Sep 13;4(9):2325967116665595. doi: 10.1177/2325967116665595. eCollection 2016 Sep 13.

Subacromial injection of autologous platelet-rich plasma versus corticosteroid for the treatment of symptomatic partial rotator cuff tears. Shams A, El-Sayed M, Gamal O, Ewes W. Eur J Orthop Surg Traumatol. 2016 Dec;26(8):837-842. Epub 2016 Aug 20.

Does application of moderately concentrated platelet-rich plasma improve clinical and structural outcome after arthroscopic repair of medium-sized to large rotator cuff tear? A randomized controlled trial. Pandey V, Bandi A, Madi S, Agarwal L, Acharya KK, Maddukuri S, Sambhaji C, Willems WJ. J Shoulder Elbow Surg. 2016 Aug;25(8):1312-22. doi: 10.1016/j.jse.2016.01.036. Epub 2016 Jun 1.

Platelet-rich plasma versus steroid injection for subacromial impingement syndrome. Say F, Gurler D, Bulbul M. J Orthop Surg (Hong Kong). 2016 Apr;24(1):62-6.

The effect of platelet-rich plasma on arthroscopic double-row rotator cuff repair: a clinical study with 12-month follow-up. Zhang Z, Wang Y, Sun J. Acta Orthop Traumatol Turc. 2016;50(2):191-7. doi: 10.3944/AOTT.2015.15.0113.

Does the Use of Platelet-Rich Plasma at the Time of Surgery Improve Clinical Outcomes in Arthroscopic Rotator Cuff Repair When Compared With Control Cohorts? A Systematic Review of Meta-analyses. Saltzman BM, Jain A, Campbell KA, Mascarenhas R, Romeo AA, Verma NN, Cole BJ. Arthroscopy. 2016 May;32(5):906-18. doi: 10.1016/j.arthro.2015.10.007. Epub 2015 Dec 23. Review.

Platelet-Rich Plasma Injection With Arthroscopic Acromioplasty for Chronic Rotator Cuff Tendinopathy: A Randomized Controlled Trial. Carr AJ, Murphy R, Dakin SG, Rombach I, Wheway K, Watkins B, Franklin SL. Am J Sports Med. 2015 Dec;43(12):2891-7. doi: 10.1177/0363546515608485. Epub 2015 Oct 23.

Efficacy of platelet-rich plasma in arthroscopic repair of full-thickness rotator cuff tears: a meta-analysis. Cai YZ, Zhang C, Lin XJ. J Shoulder Elbow Surg. 2015 Dec;24(12):1852-9. doi: 10.1016/j.jse.2015.07.035. Epub 2015 Oct 9. Review.

Do postoperative platelet-rich plasma injections accelerate early tendon healing and functional recovery after arthroscopic supraspinatus repair? A randomized controlled trial. Wang A, McCann P, Colliver J, Koh E, Ackland T, Joss B, Zheng M, Breidahl B. Am J Sports Med. 2015 Jun;43(6):1430-7. doi: 10.1177/0363546515572602. Epub 2015 Mar 19.

Clinical and structural outcomes after arthroscopic repair of full-thickness rotator cuff tears with and without platelet-rich product supplementation: a meta-analysis and meta-regression. Warth RJ, Dornan GJ, James EW, Horan MP, Millett PJ. Arthroscopy. 2015 Feb;31(2):306-20. doi: 10.1016/j.arthro.2014.09.007. Epub 2014 Nov 14. Review.

Platelet-rich plasma in rotator cuff repair: a prospective randomized study. Malavolta EA, Gracitelli ME, Ferreira Neto AA, Assunção JH, Bordalo-Rodrigues M, de Camargo OP. Am J Sports Med. 2014 Oct;42(10):2446-54. doi: 10.1177/0363546514541777. Epub 2014 Aug 1.

Does autologous leukocyte-platelet-rich plasma improve tendon healing in arthroscopic repair of large or massive rotator cuff tears? Charousset C, Zaoui A, Bellaïche L, Piterman M. Arthroscopy. 2014 Apr;30(4):428-35. doi: 10.1016/j.arthro.2013.12.018.

Platelet-rich plasma injections in the treatment of chronic rotator cuff tendinopathy: a randomized controlled trial with 1-year follow-up. Kesikburun S, Tan AK, Yilmaz B, Yaşar E, Yazicioğlu K. Am J Sports Med. 2013 Nov;41(11):2609-16. doi: 10.1177/0363546513496542. Epub 2013 Jul 26.

The role of platelet-rich plasma in arthroscopic rotator cuff repair: a systematic review with quantitative synthesis. Chahal J, Van Thiel GS, Mall N, Heard W, Bach BR, Cole BJ, Nicholson GP, Verma NN, Whelan DB, Romeo AA. Arthroscopy. 2012 Nov;28(11):1718-27. doi: 10.1016/j.arthro.2012.03.007. Epub 2012 Jun 12. Review.

Current concept for the use of PRP in arthroscopic surgery. Nourissat G, Mainard D, Kelberine F; French Arthroscopic Society (SFA). Orthop Traumatol Surg Res. 2013 Dec;99(8 Suppl):S407-10. doi: 10.1016/j.otsr.2013.10.010. Epub 2013 Nov 15. Review.

Platelet-Rich Plasma Reduces Retear Rates After Arthroscopic Repair of Small- and Medium-Sized Rotator Cuff Tears but Is Not Cost-Effective. Vavken P, Sadoghi P, Palmer M, Rosso C, Mueller AM, Szoelloesy G, Valderrabano V. Am J Sports Med. 2015 Dec;43(12):3071-6. doi: 10.1177/0363546515572777. Epub 2015 Mar 12. Review.

The Effectiveness of Platelet-Rich Plasma in the Treatment of Tendinopathy. Fitzpatrick J, Bulsara M, Zheng MH. Am J Sports Med. 2017 Jan;45(1):226-233. doi: 10.1177/0363546516643716. Epub 2016 Jul 21.

The systemic effects of platelet-rich plasma injection. Wasterlain AS, Braun HJ, Harris AH, Kim HJ, Dragoo JL. Am J Sports Med. 2013 Jan;41(1):186-93. doi: 10.1177/0363546512466383. Epub 2012 Dec 4.

Intra-articular Autologous Conditioned Plasma Injections Provide Safe and Efficacious Treatment for Knee Osteoarthritis: An FDA-Sanctioned, Randomized, Double-blind, Placebo-controlled Clinical Trial. Smith PA. Am J Sports Med. 2016 Apr;44(4):884-91. doi: 10.1177/0363546515624678. Epub 2016 Feb 1.

The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis.  Rahimzadeh P, Imani F, Faiz SH, Entezary SR, Zamanabadi MN, Alebouyeh MR.  Clin Interv Aging. 2018 Jan 4;13:73-79. doi: 10.2147/CIA.S147757. eCollection 2018.

Intra-articular injection of photo-activated platelet-rich plasma in patients with kneeosteoarthritis: a double-blind, randomized controlled pilot study.  Paterson KL, Nicholls M , Bennell KL, Bates D. BMC Musculoskelet Disord. 2016 Feb 9;17:67. doi: 10.1186/s12891-016-0920-3.

Intra-Articular Injections of Platelet-Rich Plasma versus Hyaluronic Acid in the Treatment of Osteoarthritic Knee Pain: A Randomized Clinical Trial in the Context of the Spanish National Health Care System. Montañez-Heredia E, Irízar S, Huertas PJ, Otero E, Del Valle M, Prat I, Díaz-Gallardo MS, Perán M, Marchal JA, Hernandez-Lamas Mdel C.  Int J Mol Sci. 2016 Jul 2;17(7). pii: E1064. doi: 10.3390/ijms17071064.

Randomized controlled trial comparing hyaluronic acid, platelet-rich plasma and the combination of both in the treatment of mild and moderate osteoarthritis of the knee.  Lana JFSD, Weglein A, Sampson S, Vicente EF, Huber SC, Souza CV, Ambach MA, Vincent H, Urban-Paffaro A, Onodera CMK, Annichino-Bizzacchi JM, Santana MHA, Belangero WD.  2016 Nov 29. JSRM/Vol.12 No.2, 2016; P69.

PRP in OA knee – update, current confusions and future options. Dhillon MS, Patel S, John R. SICOT J. 2017;3:27. doi: 10.1051/sicotj/2017004. Epub 2017 Mar 22.

PRP for Degenerative Cartilage Disease: A Systematic Review of Clinical Studies Laver L, Marom N, Dnyanesh L, Mei-Dan O, Espregueira-Mendes J, Gobbi A. Cartilage. 2016 Sep 1:1947603516670709. doi: 10.1177/1947603516670709.

Platelet-Rich Plasma Injections for Advanced Knee Osteoarthritis: A Prospective, Randomized, Double-Blinded Clinical Trial. Joshi Jubert N, Rodríguez L, Reverté-Vinaixa MM, Navarro A. Orthop J Sports Med. 2017 Feb 13;5(2):2325967116689386. doi: 10.1177/2325967116689386. eCollection 2017 Feb 13.

Hyaluronic Acid Versus Platelet-Rich Plasma : A Prospective, Double-Blind Randomized Controlled Trial Comparing Clinical Outcomes and Effects on Intra-articular Biology for the Treatment of Knee Osteoarthritis Cole BJ, Karas V, Hussey K, Pilz K, Fortier LA. Am J Sports Med. 2017 Feb;45(2):339-346. doi: 10.1177/0363546516665809. Epub 2016 Oct 21

Efficacy of Platelet-Rich Plasma in the Treatment of K nee Osteoarthritis: A Meta-analysis of Randomized Controlled Trials. Dai WL, Zhou AG, Zhang H, Zhang J. Arthroscopy. 2017 Mar;33(3):659-670.e1. doi: 10.1016/j.arthro.2016.09.024. Epub 2016 Dec 22.

Microfracture versus microfracture and platelet-rich plasma : arthroscopic treatment of knee chondral lesions. A two-year follow-up study. Mancò A, Goderecci R, Rughetti A, DE Giorgi S, Necozione S, Bernardi A, Calvisi V. Joints. 2016 Sep 21;4(3):142-147. eCollection 2016 Sep 21.

The efficacy of intraoperative autologous platelet gel in total knee arthroplasty: A meta-analysis. Kuang MJ, Han C, Ma JX, Li F, Zhao J, Fu L, Ma XL. Int J Surg. 2016 Dec;36(Pt A):56-65. doi: 10.1016/j.ijsu.2016.10.021. Epub 2016 Oct 19. Review.

Platelet-Rich Plasma (PRP) in Orthopedic Sports Medicine. Mlynarek RA, Kuhn AW, Bedi A. Am J Orthop (Belle Mead NJ). 2016 Jul-Aug;45(5):290-326. Review.

Leukocyte-poor platelet-rich plasma is more effective than the conventional therapy with acetaminophen for the treatment of early knee osteoarthritis. Simental-Mendía M, Vílchez-Cavazos JF, Peña-Martínez VM, Said-Fernández S, Lara-Arias J, Martínez-Rodríguez HG. Arch Orthop Trauma Surg. 2016 Dec;136(12):1723-1732. Epub 2016 Aug 9.

Efficacy of Platelet-Rich Plasma versus Hyaluronic Acid for treatment of Knee Osteoarthritis: A systematic review and meta-analysis. Sadabad HN, Behzadifar M, Arasteh F, Behzadifar M, Dehghan HR. Electron Physician. 2016 Mar 25;8(3):2115-22. doi: 10.19082/2115. eCollection 2016 Mar 25.

Does platelet-rich plasma decrease time to return to sports in acute muscle tear? A randomized controlled trial. Rossi LA, Molina Rómoli AR, Bertona Altieri BA, Burgos Flor JA, Scordo WE, Elizondo CM. Knee Surg Sports Traumatol Arthrosc. 2016 Apr 16.

Choice of intra-articular injection in treatment of k nee osteoarthritis: platelet-rich plasma , hyaluronic acid or ozone options. Duymus TM, Mutlu S, Dernek B, Komur B, Aydogmus S, Kesiktas FN. Knee Surg Sports Traumatol Arthrosc. 2017 Feb;25(2):485-492. doi: 10.1007/s00167-016-4110-5. Epub 2016 Apr 7.

Platelet-Rich Plasma Injections Were Not Better Than Hyaluronic Acid Injections for Knee Joint Degeneration. Feller J. J Bone Joint Surg Am. 2016 Feb 17;98(4):315. doi: 10.2106/JBJS.15.01441.

Effectiveness of platelet-rich plasma in the treatment of moderate k nee osteoarthritis: a randomized prospective study.Kavadar G, Demircioglu DT, Celik MY, Emre TY. J Phys Ther Sci. 2015 Dec;27(12):3863-7. doi: 10.1589/jpts.27.3863. Epub 2015 Dec 28.

Percutaneous injections of Platelet rich plasma for treatment of intrasubstance meniscal lesions. Blanke F, Vavken P, Haenle M, von Wehren L, Pagenstert G, Majewski M. Muscles Ligaments Tendons J. 2015 Oct 20;5(3):162-6. doi: 10.11138/mltj/2015.5.3.162. eCollection 2015 Oct 20.

Efficacy of Intra-articular Platelet-Rich Plasma Injections in Knee Osteoarthritis: A Systematic Review. Meheux CJ, McCulloch PC, Lintner DM, Varner KE, Harris JD. Arthroscopy. 2016 Mar;32(3):495-505. doi: 10.1016/j.arthro.2015.08.005. Epub 2015 Oct 1. Review.

The Role of Intraarticular Platelet Rich Plasma (PRP) Injection in Patients with Internal Knee Derangements. Razaq S, Ejaz A, Rao SE, Yasmeen R, Arshad MA.
J Coll Physicians Surg Pak. 2015 Sep;25(9):699-701. doi: 09.2015/JCPSP.699701.

Does intraoperative application of leukocyte-poor platelet-rich plasma during arthroscopy for knee degeneration affect postoperative pain, function and quality of life? A 12-month randomized controlled double-blind trial. Duif C, Vogel T, Topcuoglu F, Spyrou G, von Schulze Pellengahr C, Lahner M. Arch Orthop Trauma Surg. 2015 Jul;135(7):971-7. doi: 10.1007/s00402-015-2227-5. Epub 2015 May 10.

One-year follow-up of platelet-rich plasma infiltration to treat chronic proximal patellar tendinopathies. Kaux JF, Bruyere O, Croisier JL, Forthomme B, Le Goff C, Crielaard JM. Acta Orthop Belg. 2015 Jun;81(2):251-6.

Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: a randomized, double-blind, placebo-controlled trial. Görmeli G, Görmeli CA, Ataoglu B, Çolak C, Aslantürk O, Ertem K. Knee Surg Sports Traumatol Arthrosc. 2017 Mar;25(3):958-965. doi: 10.1007/s00167-015-3705-6. Epub 2015 Aug 2.

Does Intra-articular Platelet-Rich Plasma Injection Provide Clinically Superior Outcomes Compared With Other Therapies in the Treatment of Knee Osteoarthritis? A Systematic Review of Overlapping Meta-analyses. Campbell KA, Saltzman BM, Mascarenhas R, Khair MM, Verma NN, Bach BR Jr, Cole BJ. Arthroscopy. 2015 Nov;31(11):2213-21. doi: 10.1016/j.arthro.2015.03.041. Epub 2015 May 29. Review.

Platelet-Rich Plasma Intra-articular Knee Injections Show No Superiority Versus Viscosupplementation: A Randomized Controlled Trial. Filardo G, Di Matteo B, Di Martino A, Merli ML, Cenacchi A, Fornasari P, Marcacci M, Kon E. Am J Sports Med. 2015 Jul;43(7):1575-82. doi: 10.1177/0363546515582027. Epub 2015 May 7.

Effect of Leukocyte Concentration on the Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis. Riboh JC, Saltzman BM, Yanke AB, Fortier L, Cole BJ. Am J Sports Med. 2016 Mar;44(3):792-800. doi: 10.1177/0363546515580787. Epub 2015 Apr 29.

Use of Platelet-Rich Plasma in Intra-Articular Knee Injections for Osteoarthritis: A Systematic Review. Lai LP, Stitik TP, Foye PM, Georgy JS, Patibanda V, Chen B.
PM R. 2015 Jun;7(6):637-48. doi: 10.1016/j.pmrj.2015.02.003. Epub 2015 Feb 14. Review.

Platelet-rich plasma in meniscal repair: does augmentation improve surgical outcomes? Griffin JW, Hadeed MM, Werner BC, Diduch DR, Carson EW, Miller MD. Clin Orthop Relat Res. 2015 May;473(5):1665-72. doi: 10.1007/s11999-015-4170-8. Epub 2015 Feb 6.

Knee Osteoarthritis Injection Choices: Platelet – Rich Plasma (PRP) Versus Hyaluronic Acid (A one-year randomized clinical trial). Raeissadat SA, Rayegani SM, Hassanabadi H, Fathi M, Ghorbani E, Babaee M, Azma K. Clin Med Insights Arthritis Musculoskelet Disord. 2015 Jan 7;8:1-8. doi: 10.4137/CMAMD.S17894.

Platelet-rich plasma use in anterior cruciate ligament surgery: systematic review of the literature. Figueroa D, Figueroa F, Calvo R, Vaisman A, Ahumada X, Arellano S. Arthroscopy. 2015 May;31(5):981-8. doi: 10.1016/j.arthro.2014.11.022. Epub 2015 Jan 14. Review.

Platelet-rich plasma for open meniscal repair in young patients: any benefit? Pujol N, Salle De Chou E, Boisrenoult P, Beaufils P. Knee Surg Sports Traumatol Arthrosc. 2015 Jan;23(1):51-8. doi: 10.1007/s00167-014-3417-3. Epub 2014 Nov 7.

US definitions, current use, and FDA stance on use of platelet-rich plasma in sports medicine. Beitzel K, Allen D, Apostolakos J, Russell RP, McCarthy MB, Gallo GJ, Cote MP, Mazzocca AD. J Knee Surg. 2015 Feb;28(1):29-34. doi: 10.1055/s-0034-1390030. Epub 2014 Sep 30.

Can platelet-rich plasma enhance anterior cruciate ligament and meniscal repair? Hutchinson ID, Rodeo SA, Perrone GS, Murray MM. J Knee Surg. 2015 Feb;28(1):19-28. doi: 10.1055/s-0034-1387166. Epub 2014 Aug 7. Review.

Role of platelet-rich plasma in articular cartilage injury and disease. Mascarenhas R, Saltzman BM, Fortier LA, Cole BJ. J Knee Surg. 2015 Feb;28(1):3-10. doi: 10.1055/s-0034-1384672. Epub 2014 Jul 28. Review.

Use of platelet-rich plasma for patellar tendon and medial collateral ligament injuries: best current clinical practice. Andia I, Maffulli N. J Knee Surg. 2015 Feb;28(1):11-8. doi: 10.1055/s-0034-1384671. Epub 2014 Jul 4. Review.

Intraarticular platelet-rich plasma injection in the treatment of k nee osteoarthritis: review and recommendations. Pourcho AM, Smith J, Wisniewski SJ, Sellon JL. Am J Phys Med Rehabil. 2014 Nov;93(11 Suppl 3):S108-21. doi: 10.1097/PHM.0000000000000115. Review.

Are multiple platelet-rich plasma injections useful for treatment of chronic patellar tendinopathy in athletes? a prospective study. Charousset C, Zaoui A, Bellaiche L, Bouyer B. Am J Sports Med. 2014 Apr;42(4):906-11. doi: 10.1177/0363546513519964. Epub 2014 Feb 11.

Platelet-rich plasma as a treatment for patellar tendinopathy: a double-blind, randomized controlled trial. Dragoo JL, Wasterlain AS, Braun HJ, Nead KT. Am J Sports Med. 2014 Mar;42(3):610-8. doi: 10.1177/0363546513518416. Epub 2014 Jan 30. Erratum in: Am J Sports Med. 2016 Jul;44(7):NP38 .

Platelet-rich plasma : why intra-articular? A systematic review of preclinical studies and clinical evidence on PRP for joint degeneration. Filardo G, Kon E, Roffi A, Di Matteo B, Merli ML, Marcacci M. Knee Surg Sports Traumatol Arthrosc. 2015 Sep;23(9):2459-74. doi: 10.1007/s00167-013-2743-1. Epub 2013 Nov 26. Review.

Platelet-rich plasma for knee osteoarthritis. Filardo G, Di Matteo B, Kon E, Dhillon MS, Patel S, Marwaha N. Am J Sports Med. 2013 Sep;41(9):NP42-3. doi: 10.1177/0363546513502635.

Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial. Patel S, Dhillon MS, Aggarwal S, Marwaha N, Jain A. Am J Sports Med. 2013 Feb;41(2):356-64. doi: 10.1177/0363546512471299. Epub 2013 Jan 8.

Platelet rich plasma use in allograft ACL reconstructions: two-year clinical results of a MOON cohort study. Magnussen RA, Flanigan DC, Pedroza AD, Heinlein KA, Kaeding CC. Knee . 2013 Aug;20(4):277-80. doi: 10.1016/j. knee .2012.12.001. Epub 2012 Dec 24.

PRP Augmentation for ACL Reconstruction. Andriolo L, Di Matteo B, Kon E, Filardo G, Venieri G, Marcacci M. Biomed Res Int. 2015;2015:371746. doi: 10.1155/2015/371746. Epub 2015 May 5. Review. PMID:26064903

Growth factors and platelet rich plasma in anterior cruciate ligament reconstruction. Bissell L, Tibrewal S, Sahni V, Khan WS. Curr Stem Cell Res Ther. 2015;10(1):19-25. Review.

Patellar tendon healing with platelet-rich plasma : a prospective randomized controlled trial. de Almeida AM, Demange MK, Sobrado MF, Rodrigues MB, Pedrinelli A, Hernandez AJ. Am J Sports Med. 2012 Jun;40(6):1282-8. doi: 10.1177/0363546512441344. Epub 2012 Apr 2.

Fibrin Scaffold as a Carrier for Mesenchymal Stem Cells and Growth Factors in Shoulder Rotator Cuff Repair. Voss A, McCarthy MB, Allen D, Cote MP, Beitzel K, Imhoff AB, Mazzocca AD. Arthrosc Tech. 2016 May 2;5(3):e447-51. doi: 10.1016/j.eats.2016.01.029. eCollection 2016 May 2.

Mesenchymal Stem Cell Secretome: A Potential Tool for the Prevention of Muscle Degenerative Changes Associated With Chronic Rotator Cuff Tears. Sevivas N, Teixeira FG, Portugal R, Araújo L, Carriço LF, Ferreira N, Vieira da Silva M, Espregueira-Mendes J, Anjo S, Manadas B, Sousa N, Salgado AJ. Am J Sports Med. 2016 Aug 8. pii: 0363546516657827.

A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions. Centeno CJ, Al-Sayegh H, Freeman MD, Smith J, Murrell WD, Bubnov R. Int Orthop. 2016 Aug;40(8):1755-65. doi: 10.1007/s00264-016-3162-y. Epub 2016 Mar 30.

Stem cell therapy in the management of shoulder rotator cuff disorders. Valencia Mora M, Ruiz Ibán MA, Díaz Heredia J, Barco Laakso R, Cuéllar R, García Arranz M. World J Stem Cells. 2015 May 26;7(4):691-9. doi: 10.4252/wjsc.v7.i4.691. Review.

Bone marrow stimulation at the footprint of arthroscopic surface-holding repair advances cuff repair integrity. Taniguchi N, Suenaga N, Oizumi N, Miyoshi N, Yamaguchi H, Inoue K, Chosa E. J Shoulder Elbow Surg. 2015 Jun;24(6):860-6. doi: 10.1016/j.jse.2014.09.031. Epub 2014 Dec 2.

Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study. Hernigou P, Flouzat Lachaniette CH, Delambre J, Zilber S, Duffiet P, Chevallier N, Rouard H. Int Orthop. 2014 Sep;38(9):1811-8. doi: 10.1007/s00264-014-2391-1. Epub 2014 Jun 7.

The future role of mesenchymal stem cells in the management of shoulder disorders. Beitzel K, Solovyova O, Cote MP, Apostolakos J, Russell RP, McCarthy MB, Mazzocca AD. Arthroscopy. 2013 Oct;29(10):1702-11. doi: 10.1016/j.arthro.2013.06.014. Epub 2013 Aug 21. Review.

Biologically enhanced healing of the human rotator cuff: 8-month postoperative histological evaluation. Protzman NM, Stopyra GA, Hoffman JK. Orthopedics. 2013 Jan;36(1):38-41. doi: 10.3928/01477447-20121217-06.

Exploring the application of stem cells in tendon repair and regeneration. Ahmad Z, Wardale J, Brooks R, Henson F, Noorani A, Rushton N. Arthroscopy. 2012 Jul;28(7):1018-29. doi: 10.1016/j.arthro.2011.12.009. Epub 2012 Feb 28. Review.

Intra-articular Implantation of Mesenchymal Stem Cells, Part 1: A Review of the Literature for Prevention of Postmeniscectomy Osteoarthritis. Kraeutler MJ, Mitchell JJ, Chahla J, McCarty EC, Pascual-Garrido C. Orthop J Sports Med. 2017 Jan 19;5(1):2325967116680815. doi: 10.1177/2325967116680815. eCollection 2017 Jan 19.

Intra-articular Implantation of Mesenchymal Stem Cells, Part 2: A Review of the Literature for Meniscal Regeneration. Kraeutler MJ, Mitchell JJ, Chahla J, McCarty EC, Pascual-Garrido C.
Orthop J Sports Med. 2017 Jan 19;5(1):2325967116680814. doi: 10.1177/2325967116680814. eCollection 2017 Jan 19.

No evidence for the use of stem cell therapy for tendon disorders: a systematic review. Pas HI, Moen MH, Haisma HJ, Winters M. Br J Sports Med. 2017 Jan 11. pii: bjsports-2016-096794. doi: 10.1136/bjsports-2016-096794.

Identifying the optimum source of mesenchymal stem cells for use in knee surgery. Davies BM, Snelling SJ, Quek L, Hakimi O, Ye H, Carr A, Price AJ. J Orthop Res. 2016 Dec 9. doi: 10.1002/jor.23501.

Efficacy of mesenchymal stem cells in treating patients with osteoarthritis of the knee: A meta-analysis. Cui GH, Wang YY, Li CJ, Shi CH, Wang WS. Exp Ther Med. 2016 Nov;12(5):3390-3400. Epub 2016 Oct 11.

Stem cells and knee osteoarthritis: a legitimate treatment option? Wheeler J, Dabirrahmani D, Hope N. ANZ J Surg. 2016 Nov;86(11):857-858. doi: 10.1111/ans.13640. Review.

Biologic agents for anterior cruciate ligament healing: A systematic review. Di Matteo B, Loibl M, Andriolo L, Filardo G, Zellner J, Koch M, Angele P. World J Orthop. 2016 Sep 18;7(9):592-603. doi: 10.5312/wjo.v7.i9.592. eCollection 2016 Sep 18.

A Prospective, Single-Blind, Placebo-Controlled Trial of Bone Marrow Aspirate Concentrate for Knee Osteoarthritis. Shapiro SA, Kazmerchak SE, Heckman MG, Zubair AC, O’Connor MI. Am J Sports Med. 2017 Jan;45(1):82-90. doi: 10.1177/0363546516662455. Epub 2016 Sep 30.

Combination of Intra-Articular and Intraosseous Injections of Platelet Rich Plasma for Severe Knee Osteoarthritis: A Pilot Study. Sánchez M, Delgado D, Sánchez P, Muiños-López E, Paiva B, Granero-Moltó F, Prósper F, Pompei O, Pérez JC, Azofra J, Padilla S, Fiz N. Biomed Res Int. 2016;2016:4868613. doi: 10.1155/2016/4868613. Epub 2016 Jul 4.

A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions. Centeno CJ, Al-Sayegh H, Freeman MD, Smith J, Murrell WD, Bubnov R. Int Orthop. 2016 Aug;40(8):1755-65. doi: 10.1007/s00264-016-3162-y. Epub 2016 Mar 30.

Concentrated Bone Marrow Aspirate for the Treatment of Chondral Injuries and Osteoarthritis of the Knee: A Systematic Review of Outcomes. Chahla J, Dean CS, Moatshe G, Pascual-Garrido C, Serra Cruz R, LaPrade RF. Orthop J Sports Med. 2016 Jan 13;4(1):2325967115625481. doi: 10.1177/2325967115625481. eCollection 2016 Jan 13.

Assessment of clinical and MRI outcomes after mesenchymal stem cell implantation in patients with knee osteoarthritis: a prospective study. Kim YS, Choi YJ, Lee SW, Kwon OR, Suh DS, Heo DB, Koh YG. Osteoarthritis Cartilage. 2016 Feb;24(2):237-45. doi: 10.1016/j.joca.2015.08.009. Epub 2015 Aug 28.

Stem cells in degenerative orthopaedic pathologies: effects of aging on therapeutic potential. Atesok K, Fu FH, Sekiya I, Stolzing A, Ochi M, Rodeo SA. Knee Surg Sports Traumatol Arthrosc. 2017 Feb;25(2):626-636. doi: 10.1007/s00167-015-3763-9. Epub 2015 Aug 23. Review.

Anterior cruciate ligament tears treated with percutaneous injection of autologous bone marrow nucleated cells: a case series. Centeno CJ, Pitts J, Al-Sayegh H, Freeman MD. J Pain Res. 2015 Jul 31;8:437-47. doi: 10.2147/JPR.S86244. eCollection 2015 Jul 31.

Postmeniscectomy Meniscus Growth With Stem Cells: Where Are We Now? McCrum CL, Vangsness CT. Sports Med Arthrosc. 2015 Sep;23(3):139-42. doi: 10.1097/JSA.0000000000000073. Review.

Mesenchymal stem cell implantation in knee osteoarthritis: an assessment of the factors influencing clinical outcomes. Kim YS, Choi YJ, Koh YG. Am J Sports Med. 2015 Sep;43(9):2293-301. doi: 10.1177/0363546515588317. Epub 2015 Jun 25.

Efficacy of mesenchymal stem cells injection for the management of knee osteoarthritis: a systematic review and meta-analysis. Xia P, Wang X, Lin Q, Li X. Int Orthop. 2015 Dec;39(12):2363-72. doi: 10.1007/s00264-015-2785-8. Epub 2015 May 6. Review.

The role of stem cells and tissue engineering in orthopaedic sports medicine: current evidence and future directions. Hogan MV, Walker GN, Cui LR, Fu FH, Huard J. Arthroscopy. 2015 May;31(5):1017-21. doi: 10.1016/j.arthro.2014.11.033. Epub 2015 Feb 25.

Biological augmentation and tissue engineering approaches in meniscus surgery. Moran CJ, Busilacchi A, Lee CA, Athanasiou KA, Verdonk PC. Arthroscopy. 2015 May;31(5):944-55. doi: 10.1016/j.arthro.2014.11.044. Epub 2015 Feb 14. Review.

FDA regulation of adult stem cell therapies as used in sports medicine. Chirba MA, Sweetapple B, Hannon CP, Anderson JA. J Knee Surg. 2015 Feb;28(1):55-62. doi: 10.1055/s-0034-1398470. Epub 2015 Jan 20. Review.

Current concepts: the role of mesenchymal stem cells in the management of knee osteoarthritis. Wolfstadt JI, Cole BJ, Ogilvie-Harris DJ, Viswanathan S, Chahal J. Sports Health. 2015 Jan;7(1):38-44. doi: 10.1177/1941738114529727.

Can a meniscus really regenerate so easily? A Level-I study says it can but not for everyone: Commentary on an article by C. Thomas Vangsness Jr., MD, et al.: “Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study”. Ellis HB. J Bone Joint Surg Am. 2014 Jan 15;96(2):e14. doi: 10.2106/JBJS.M.01330.

Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study. Vangsness CT Jr, Farr J 2nd, Boyd J, Dellaero DT, Mills CR, LeRoux-Williams M. J Bone Joint Surg Am. 2014 Jan 15;96(2):90-8. doi: 10.2106/JBJS.M.00058.

Mesenchymal stem cell injections improve symptoms of knee osteoarthritis. Koh YG, Jo SB, Kwon OR, Suh DS, Lee SW, Park SH, Choi YJ. Arthroscopy. 2013 Apr;29(4):748-55. doi: 10.1016/j.arthro.2012.11.017. Epub 2013 Jan 29.

Full ArticleAge and Sex Influence the Mesenchymal Stem Cell Composition of Bone Marrow Aspirate Concentrate (BMAC) Alexander Beletsky BA, Brandon Manderle MD, Paria Mirmonsef PhD, Ani K. Gowd BS, Jorge Chahla MD PhD, Adam Yanke MD PhD, Brian Forsythe MD, Brian J. Cole MD, Nikhil N. Verma MD

Full Article